I use them when I need to change the baby on one of those restroom changing tables. Maybe it's the "germ-a-phobe" in me but who knows how many not so tidy diapers have been changed there before I arrived.
I use the socks on the baby's hands so he won't get all those lovely germs in his mouth when his hands return there (as they always do). I simply slip them on his hands before laying him down on the changing table and remove them once he is snuggled back into his carrier. Socks go into the hamper when we return home. Easy Breezy, give it a try!